Beta-cell pathology

The team of Arnaud Zaldumbide focuses on the pathology of beta cells. The lab discovered that beta cells under stress can produce misfolded proteins that trigger autoimmune responses, contributing to their own destruction. The lab also explores ways to evade the immune system, by creating “stealth” beta cells that can survive the autoimmunity in T1D. Furthermore, research is conducted to understand the molecular process behind beta cell disfunction. Understanding these mechanisms could lead to new therapeutic strategies to protect beta cells in T1D.